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HPLC Columns

Target-HIC

Packing overview:
The target HIC series of hydrophobic interaction chromatographic columns are specially designed and developed for the efficient separation of proteins, oligonucleotides and peptides. As shown in the table below, the target HIC series is composed of two kinds of ligands (butyl and phenyl) with different hydrophobicity from low to high, which are bonded to PS / DVB packings by butyl.
Hydrophobic packing without pore and narrow particle size distribution can effectively isolate proteins such as monoclonal antibody (mAb), antibody coupled drug (ADC), DNA and oligonucleotide related protein fragments.

chromatographic column

Target hicb (butyl) Target HICP (phenyl)
stroma PS / DVB with no hole, sphere and high cross connection
Particle size 5μm and 10μM
ph stability

2-9

Maximum operating temperature (℃) 60
Maximum operating pressure PSI 5000
Mobile phase compatibility Conventional aqueous and organic solvents

The characteristics of target HIC series hydrophobic interaction column are as follows
Monodisperse granular filler with high column efficiency and high resolution
Three kinds of particle size selection: 1.7, 5 and 10 μ m, meeting the requirements of UPLC, HPLC analysis and semi preparation
PH range: 2 ~ 9
High pressure resistance: 5 um particle size packing can withstand 5000 psi
It is especially suitable for the separation and analysis of monoclonal antibody and its antibody conjugate (ADC)

Excellent durability and stability:
The chromatographic conditions were as follows
Chromatographic column: target hicb 5um 4.6 * 50mm
Mobile phase: a (2m ammonium sulfate in 0.1M sodium phosphate, pH7.0), B (0.1M phosphate, pH7.0)
Gradient: 0-15min (0-100% B), 15-20min (100% B);
Flow rate: 0.4ml/min
Detector: UV @ 214nm
Column temperature: 25 ℃
Samples: ovalbumin (1.0 mg / ml), chymotrypsiongen (0.5 mg / ml),
UL: 4ul

Excellent inter assay reproducibility:
The chromatographic conditions were as follows
Chromatographic column: target hicb 5um 4.6 * 50mm
Mobile phase: a (2m ammonium sulfate in 0.025m sodium phosphate, pH 7.0), B (0.025m sodium phosphate, pH7.0), C (IPA, 100%)
Flow rate: 0.5ml/min
Detector: UV @ 214nm
Column temperature: 25 ℃
Sample: ADC (1.0mg / ml) in 0.025m sodium phosphate
Injection volume: 10ul

Order information:

Filler name

Particle size

Specifications

Part No

Target-HICb

5um

4.6*50mm

75005-4605

Target-HICb

5um

4.6*100mm

75005-4610

Target-HICb

5um

4.6*250mm

75005-4625

Target-HICp

5um

4.6*50mm

77005-4605

Target-HICp

5um

4.6*100mm

77005-4610

Target-HICp

5um

4.6*250mm

77005-4625

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